The collision on the Coolmillish Road in County Armagh was reported to police on Friday morning.
The fire service said two people were cut out of a car following the collision in the Mullaghbrack Road area.
Daniel McCallister died in hospital and Robert Lee was killed at the scene.
Ciera Grimley, Patrick Grimley and Ciara McIlvenna died following the crash in November.
November is quiet month for some local retailers, as shoppers hold out for deals and shop online.
Two men, aged 32 and 34, are arrested after officers searched a premises in County Armagh.
Rachael Lowry, who was 17, died after the single-vehicle crash in Markethill in September 2020.
Judith McMullan, from Whitecross in County Armagh, was killed in the incident near Markethill.
Rachael Lowry was 17 when the vehicle she was a passenger in crashed in September 2020.
