Part of the A684 will close from 26 October in the final part of the Sedbergh roadworks project.
The works, running from 14 September to 16 October, form part of a scheme improving the A684.
Westmorland and Furness Council says it will try to keep disruptions to a minimum.
It is hoped the work on the C5101 near the Dent Head Viaduct will be complete in seven weeks.
