Dominic Charles-Turner and Moses Edwards indicate they will deny a charge of arson with intent to endanger life.
Dominique Charles-Turner is charged with arson with intent to endanger life at a former synagogue in Whitechapel.
A 31-year-old man is in police custody arrested on suspicion of arson with intent to endanger life.
Moses Edwards is accused with arson with intent to endanger life over the fire.
The 45-year-old man and 52-year-old woman were arrested on Sunday and taken into police custody.
The fire broke out at the former East London Central Synagogue on Tuesday morning.
Additional investment aims to keep specialised sickle cell emergency care at the Royal London Hospital.
Stallholders reject claims made by residents that the Petticoat Lane Food Court is causing issues.
