Production of the former Morland brand will shift from Suffolk to Bedford.
Young adults are drinking less, so the likes of Nick Mackenzie are having to expand the appeal of pubs.
Hundreds of people campaigned and invested to buy and reopen the venue, residents say.
Residents are reacting to Greene King's decision to move out of its central Westgate Street brewery.
Greene King aims to begin construction this year, with the brewery operational by 2027.
The business says a shake-up is needed for it to “thrive in these challenging times”.
About £326,000 has been raised so far with some donations coming from France and the US.
Greene King calls time on its base of more than 200 years in Bury St Edmunds.
The company says it has been "brewing in Bury St Edmunds for over 200 years".
