Jim, 14, and Felicity, 18, finish their challenge at Robin Hood's Bay after 15 days of pedalling.
Bex Hind says she "refused to sit down and give up" after being diagnosed with a rare cancer.
They include a welcome boost for three campaigning dads who lost their daughters to suicide.
The government says lessons on dealing with suicidal thoughts will be compulsory in schools.
The trio, who each lost a daughter to suicide, will trek round Anglesey to save the Papyrus service.
The men have raised £1m, which has been used by suicide prevention charity Papyrus to open offices.
The fathers, including Andy Airey from Cumbria, all lost their daughters to suicide.
The men, who lost their daughters to suicide, want more mental health lessons in schools.
Three Dads Walking are calling for the subject to be a compulsory part of the school curriculum.
