Police say the route reopened shortly after midnight on Saturday, about 19 hours after the crash.
The development could also contain land for a school, shops and a traveller site.
National Highways said the road would be closed in phases, between Gamston and Bingham, from Monday.
Local NHS bosses say the expansion is needed to support a growing population.
Police said there were not currently believed to be any serious injuries following the crash.
Gamston near Retford will be among specific locations nationwide to undergo mosquito surveillance.
Prof Jonathan Ball says tropical viruses are moving north but people should not be "too concerned".
Firefighters are tackling the blaze on the A52 in Nottinghamshire, between Gamston and West Bridgford.
Police and the fire service were called to the scene following the crash on the A52.
